Stemolecule™ Wnt Inhibitor IWP-4
04-0036 / 04-0036-50
Brand: Stemolecule
Wnt Inhbitor IWP-4 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity.
- 2-(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-ylthio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
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Currency:
Product name | Product code | Pack size | Price | Price (USD) | Price (GBP) | Price (EUR) |
---|---|---|---|---|---|---|
Stemolecule™ Wnt Inhibitor IWP-4 | 04-0036 | 2 mg | (select above) | $ 120.00 | £ 99.00 | € 115.00 |
Stemolecule™ Wnt Inhibitor IWP-4 | 04-0036-50 | 50 mg | (select above) | $ 1,092.00 | £ 886.00 | € 1,046.00 |
Note: prices shown do not include shipping and handling charges.
Product Information
Wnt Inhibitor IWP-4 was identified in a high throughput screen for antagonists of the Wnt / β-catenin pathway. Wnt Inhibitor IWP-4 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, there by blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin1.
New 50 mg size now available.
Stemgent and the Stemolecule brand name are trademarks of REPROCELL Inc., Japan.
Product Name: Stemolecule Wnt Inhibitor IWP-4
Catalog Number: 04-0036
Size: 2 mg
Alternate Name(s): 2-(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-ylthio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
Chemical Formula: C23H20N4O3S3
Molecular Weight: 496.62
CAS Number: 686772-17-8
Purity: Greater than 96 % by HPLC analysis
Formulation: White solid
Solubility: This molecule is reported to be soluble in DMSO at 1.2 mM.
Reconstitution: For a 1.2 mM concentrated stock solution of Wnt Inhibitor IWP-4, reconstitute the compound by adding 3.36 mL of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37 °C for 2 to 5 minutes. For use in cell culture, keep the total DMSO concentration less than 0.1%.
Storage and Stability: Store powder at 4 °C protected from light. Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at − 20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.
Quality Control: The purity of Wnt Inhibitor IWP-4 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of Wnt Inhibitor IWP-4 was tested on mouse embryonic stem cells.
Specification Sheets:
Safety Data Sheets:
Additional Publications
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