Vasoconstriction in Human Coronary Arteries (5-HT Receptor – 5-HT)
Reference number: B003
Assay type: | Blood Vessels |
Tissue: | Human Coronary Artery (Healthy) |
Target: | 5-HT receptor |
Control Compound: | 5-HT |
Study Type: | Wire Myography |
Functional Endpoint: | Vasoconstriction |
Vasoconstriction in Human Coronary Arteries (Opioid and Opioid-Like Receptors)
Reference number: B004
Assay type: | Blood Vessels |
Tissue: | Human Coronary Artery (Healthy) |
Target: | Opioid & opioid-like receptors |
Control Compound: | Mephedrone |
Study Type: | Wire Myography |
Functional Endpoint: | Vasoconstriction |
Vasoconstriction in Human Coronary Arteries (Angiotensin Receptor)
Reference number: B007
Assay type: | Blood Vessels |
Tissue: | Human Coronary Artery (Healthy) |
Target: | Angiotensin receptor |
Control Compound: | Angiotensin II |
Study Type: | Organ bath |
Functional Endpoint: | Vasoconstriction |
Vasoconstriction in Human Coronary Arteries (Vasopressin & Oxytocin Receptors)
Reference number: B008
Assay type: | Blood Vessels |
Tissue: | Human Coronary Artery (Healthy) |
Target: | Vasopressin & oxytocin receptors |
Control Compound: | 8-arginine vasopressin |
Study Type: | Organ bath |
Functional Endpoint: | Vasoconstriction |
Vasodilatation in Human Subcutaneous Resistance Arteries (Acetylcholine Receptor)
Reference number: B016
Assay type: | Blood Vessels |
Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
Target: | Acetylcholine receptor |
Control Compound: | Acetylcholine |
Study Type: | Wire Myography |
Functional Endpoint: | Vasodilatation |
Vasodilatation in Human Subcutaneous Resistance Arteries (Vasopressin & Oxytocin Receptors)
Reference number: B017
Assay type: | Blood Vessels |
Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
Target: | Vasopressin & oxytocin receptors |
Control Compound: | Desmopressin |
Study Type: | Wire Myography |
Functional Endpoint: | Vasodilatation |
Vasodilatation in Human Subcutaneous Resistance Arteries (Nitric Oxide Donor)
Reference number: B019
Assay type: | Blood Vessels |
Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
Target: | Nitric oxide donor |
Control Compound: | SNP |
Study Type: | Wire Myography |
Functional Endpoint: | Vasodilatation |
Vasoconstriction in Human Subcutaneous Resistance Arteries (Adrenoceptor)
Reference number: B020
Assay type: | Blood Vessels |
Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
Target: | Adrenoceptor |
Control Compound: | Phenylephrine |
Study Type: | Wire Myography |
Functional Endpoint: | Vasodilatation |
Vasoconstriction in Human Subcutaneous Resistance Arteries (Prostanoid Receptor)
Reference number: B021
Assay type: | Blood Vessels |
Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
Target: | Prostanoid receptor |
Control Compound: | U46619 |
Study Type: | Wire Myography |
Functional Endpoint: | Vasoconstriction |
Vasodilatation in Ischaemic Human Subcutaneous Resistance Arteries (Bradykinin Receptor)
Reference number: B022
Assay type: | Blood Vessels |
Tissue: | Human Subcutaneous Resistance Artery (Ischaemic) |
Target: | Bradykinin receptor |
Control Compound: | Bradykinin |
Study Type: | Wire Myography |
Functional Endpoint: | Vasodilatation |
Vasoconstriction in Human Coronary Arteries (5-HT Receptor – Sumatriptan)
Reference number: B028
Assay type: | Blood Vessels |
Tissue: | Human Coronary Artery (Healthy) |
Target: | 5-HT receptor |
Control Compound: | Sumatriptan |
Study Type: | Wire Myography |
Functional Endpoint: | Vasoconstriction |
Vasoconstriction in Denuded Human Coronary Arteries (5-HT Receptor)
Reference number: B030
Assay type: | Blood Vessels |
Tissue: | Human Coronary Artery (Healthy – Denuded) |
Target: | 5-HT receptor |
Control Compound: | 5-HT |
Study Type: | Organ bath |
Functional Endpoint: | Vasoconstriction |
Vasodilatation in Human Subcutaneous Resistance Arteries (PDE3 Receptor)
Reference number: B034
Assay type: | Blood Vessels |
Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
Target: | PDE3 |
Control Compound: | Milrinone |
Study Type: | Wire Myography |
Functional Endpoint: | Vasodilatation |
Vasodilatation in Human Subcutaneous Resistance Arteries (Bradykinin Receptor)
Reference number: B035
Assay type: | Blood Vessels |
Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
Target: | Bradykinin receptor |
Control Compound: | Bradykinin |
Study Type: | Wire Myography |
Functional Endpoint: | Vasodilatation |
Vasoconstriction in Atherosclerotic Human Subcutaneous Resistance Arteries (Angiotensin Receptor)
Reference number: B037
Assay type: | Blood Vessels |
Tissue: | Human Resistance Artery (Atherosclerotic) |
Target: | Angiotensin receptor |
Control Compound: | PDA-angiotensin 1 |
Study Type: | Wire Myography |
Functional Endpoint: | Vasoconstriction |
Vasodilatation in Ischaemic Human Subcutaneous Resistance Arteries (Nitric Oxide Donor)
Reference number: B038
Assay type: | Blood Vessels |
Tissue: | Human Subcutaneous Resistance Artery (Ischaemic) |
Target: | Nitric oxide donor |
Control Compound: | SNP |
Study Type: | Wire Myography |
Functional Endpoint: | Vasodilatation |
Vasodilatation in Human Skeletal Muscle Arteries (Acetycholine Receptor)
Reference number: B039
Assay type: | Blood Vessels |
Tissue: | Human Skeletal Muscle Artery (Healthy) |
Target: | Acetylcholine receptor |
Control Compound: | Acetylcholine |
Study Type: | Wire Myography |
Functional Endpoint: | Vasodilatation |
Vasodilatation in Human Skeletal Muscle Arteries (Nitric Oxide Donor)
Reference number: B040
Assay type: | Blood Vessels |
Tissue: | Human Skeletal Muscle Artery (Healthy) |
Target: | Nitric oxide donor |
Control Compound: | SNP |
Study Type: | Wire Myography |
Functional Endpoint: | Vasodilatation |
Contractile Force in Electrically Stimulated Human Atrial Pectinate Muscle (Adrenoceptors – Isoprenaline)
Reference number: B043
Assay type: | Cardiac Muscle |
Tissue: | Human Atrial Pectinate Muscle (Healthy) |
Target: | Adrenoceptor |
Control Compound: | Isoprenaline |
Study Type: | EFS organ bath |
Functional Endpoint: | Contractility |
Contractile Force in Electrically Stimulated Human Ventricular Trabeculae Muscle (5-HT Receptor)
Reference number: B047
Assay type: | Cardiac Muscle |
Tissue: | Human Ventricular Trabeculae Muscle (Healthy) |
Target: | 5-HT receptor |
Control Compound: | 5-HT |
Study Type: | EFS organ bath |
Functional Endpoint: | Contractility |
Contractile Force in Electrically Stimulated Human Atrial Pectinate Muscle (5-HT Receptor)
Reference number: B048
Assay type: | Cardiac Muscle |
Tissue: | Human Atrial Pectinate Muscle (Healthy) |
Target: | 5-HT receptor |
Control Compound: | 5-HT |
Study Type: | EFS organ bath |
Functional Endpoint: | Contractility |
Contractile Force in Electrically Stimulated Human Atrial Pectinate Muscle (Adrenoceptors – Salbutamol)
Reference number: B049
Assay type: | Cardiac Muscle |
Tissue: | Human Atrial Pectinate Muscle (Healthy) |
Target: | Adrenoceptor |
Control Compound: | Salbutamol |
Study Type: | EFS organ bath |
Functional Endpoint: | Contractility |
Contractile Force in Electrically Stimulated Human Atrial Pectinate Muscle (PDE3 Receptor)
Reference number: B050
Assay type: | Cardiac Muscle |
Tissue: | Human Atrial Pectinate Muscle (Healthy) |
Target: | PDE3 |
Control Compound: | Milrinone |
Study Type: | EFS organ bath |
Functional Endpoint: | Contractility |
Bronchodilatation in Secondary Healthy Human Airways (Adrenoceptor – Isoprenaline)
Reference number: B052
Assay type: | Respiratory |
Tissue: | Human Tertiary Or Lower Airways (Healthy) |
Target: | Adrenoceptor |
Control Compound: | Isoprenaline |
Study Type: | Wire Myography |
Functional Endpoint: | Bronchodilatation |
Bronchoconstriction in Secondary Asthmatic Human Airways (Acetylcholine Receptor)
Reference number: B053
Assay type: | Respiratory |
Tissue: | Human Secondary Airways (Asthmatic) |
Target: | Acetylcholine receptor |
Control Compound: | Carbachol |
Study Type: | Organ bath |
Functional Endpoint: | Bronchoconstriction |
Bronchodilatation in Secondary Asthmatic Human Airways (Adrenoceptor)
Reference number: B054
Assay type: | Respiratory |
Tissue: | Human Secondary Airways (Asthmatic) |
Target: | Adrenoceptor |
Control Compound: | Salbutamol |
Study Type: | Organ bath |
Functional Endpoint: | Bronchodilatation |
Bronchoconstriction in Tertiary or Lower Healthy Human Airways (Prostanoid Receptor)
Reference number: B055
Assay type: | Respiratory |
Tissue: | Human Tertiary Or Lower Airways (Healthy) |
Target: | Prostanoid receptor |
Control Compound: | U46619 |
Study Type: | Wire Myography |
Functional Endpoint: | Bronchoconstriction |
Bronchodilatation in Tertiary or Lower Healthy Human Airways (Adrenoceptor – Salbutamol)
Reference number: B056
Assay type: | Respiratory |
Tissue: | Human Tertiary Or Lower Airways (Healthy) |
Target: | Adrenoceptor |
Control Compound: | Salbutamol |
Study Type: | Wire Myography |
Functional Endpoint: | Bronchodilatation |
Bronchoconstriction in Tertiary or Lower Healthy Human Airways (Acetylcholine Receptor)
Reference number: B057
Assay type: | Respiratory |
Tissue: | Human Tertiary Or Lower Airways (Healthy) |
Target: | Acetylcholine receptor |
Control Compound: | Acetylcholine |
Study Type: | Wire Myography |
Functional Endpoint: | Bronchoconstriction |
Bronchodilatation in Tertiary or Lower Healthy Human Airways (Adrenoceptor – Isoprenaline)
Reference number: B058
Assay type: | Respiratory |
Tissue: | Human Tertiary Or Lower Airways (Healthy) |
Target: | Adrenoceptor |
Control Compound: | Isoprenaline |
Study Type: | Wire Myography |
Functional Endpoint: | Bronchodilatation |
Bronchodilatation in Tertiary or Lower Airways COPD (Adrenoceptor)
Reference number: B059
Assay type: | Respiratory |
Tissue: | Human Tertiary Or Lower Airways (COPD) |
Target: | Adrenoceptor |
Control Compound: | Isoprenaline |
Study Type: | Wire Myography |
Functional Endpoint: | Bronchodilatation |
Bronchoconstriction in Denuded Secondary Healthy Human Airways (Acetylcholine Receptor)
Reference number: B060
Assay type: | Respiratory |
Tissue: | Human Secondary Airways (Healthy – Denuded) |
Target: | Acetylcholine receptor |
Control Compound: | Carbachol |
Study Type: | Organ bath |
Functional Endpoint: | Bronchoconstriction |
Bronchoconstriction in Denuded Secondary Healthy Human Airways (Histamine Receptor)
Reference number: B061
Assay type: | Respiratory |
Tissue: | Human Secondary Airways (Healthy – Denuded) |
Target: | Histamine receptor |
Control Compound: | Histamine |
Study Type: | Organ bath |
Functional Endpoint: | Bronchoconstriction |
Bronchodilatation in Tertiary or Lower Human Airways (Adrenoceptors – Formoterol)
Reference number: B065
Assay type: | Respiratory |
Tissue: | Human Tertiary Or Lower Airways (Healthy) |
Target: | Adrenoceptor |
Control Compound: | Formoterol |
Study Type: | Wire Myography |
Functional Endpoint: | Bronchodilatation |
Bronchodilatation in Tertiary or Lower Human Airways (Adrenoceptors – Salbutamol)
Reference number: B066
Assay type: | Respiratory |
Tissue: | Human Tertiary Or Lower Airways (Healthy) |
Target: | |
Control Compound: | Salbutamol |
Study Type: | Wire Myography |
Functional Endpoint: | Bronchodilatation |
Bronchodilatation in Tertiary or Lower Asthmatic Human Airways (Adrenoceptor – Formoterol)
Reference number: B067
Assay type: | Respiratory |
Tissue: | Human Tertiary Or Lower Airways (Asthmatic) |
Target: | Adrenoceptor |
Control Compound: | Formoterol |
Study Type: | Wire Myography |
Functional Endpoint: | Bronchodilatation |
Bronchodilatation in Tertiary or Lower Asthmatic Human Airways (Adrenoceptor – Salbutamol)
Reference number: B068
Assay type: | Respiratory |
Tissue: | Human Tertiary Or Lower Airways (Asthmatic) |
Target: | Adrenoceptor |
Control Compound: | Salbutamol |
Study Type: | Wire Myography |
Functional Endpoint: | Bronchodilatation |
Bronchodilatation in Tertiary or Lower Asthmatic Human Airways (Adrenoceptor – Salmeterol)
Reference number: B069
Assay type: | Respiratory |
Tissue: | Human Tertiary Or Lower Airways (Asthmatic) |
Target: | Adrenoceptor |
Control Compound: | Salmeterol |
Study Type: | Wire Myography |
Functional Endpoint: | Bronchodilatation |
Relaxation in Human Bladder (Adrenoceptor – Isoproterenol)
Reference number: B070
Assay type: | GU |
Tissue: | Human Bladder (Healthy) |
Target: | Adrenoceptor |
Control Compound: | Isoproterenol |
Study Type: | Organ bath |
Functional Endpoint: | Relaxation |
Relaxation in Human Ureter (Adrenoceptor – Isoprenaline)
Reference number: B071
Assay type: | GU |
Tissue: | Human Ureter (Healthy) |
Target: | Adrenoceptor |
Control Compound: | Isoprenaline |
Study Type: | Organ bath |
Functional Endpoint: | Relaxation |
Contraction in Human Urethra (Adrenoceptor – Phenylephrine)
Reference number: B072
Assay type: | GU |
Tissue: | Human Urethra (Healthy) |
Target: | Adrenoceptor |
Control Compound: | Phenylephrine |
Study Type: | Organ bath |
Functional Endpoint: | Contractility |
Contraction in Human Uterus (Vasopressin & Oxytocin Receptor – Oxytocin)
Reference number: B078
Assay type: | GU |
Tissue: | Human Uterus (Healthy) |
Target: | Vasopressin & oxytocin receptors |
Control Compound: | Oxytocin |
Study Type: | Organ bath |
Functional Endpoint: | Contractility |
Contraction in Human Uterus (Vasopressin & Oxytocin Receptor – Vasopressin)
Reference number: B079
Assay type: | GU |
Tissue: | Human Uterus (Healthy) |
Target: | Vasopressin & oxytocin receptors |
Control Compound: | Vasopressin |
Study Type: | Organ bath |
Functional Endpoint: | Contractility |
Relaxation in Human Uterus (Nitric Oxide Donor)
Reference number: B081
Assay type: | GU |
Tissue: | Human Uterus (Healthy) |
Target: | Nitric oxide donor |
Control Compound: | SNP |
Study Type: | Organ bath |
Functional Endpoint: | Relaxation |
Relaxation in Human Uterus (Adrenoceptor – Isoprenaline)
Reference number: B082
Assay type: | GU |
Tissue: | Human Uterus (Healthy) |
Target: | Adrenoceptor |
Control Compound: | Isoprenaline |
Study Type: | Organ bath |
Functional Endpoint: | Relaxation |
Relaxation in Human Uterus (Calcium Channels)
Reference number: B083
Assay type: | GU |
Tissue: | Human Uterus (Healthy) |
Target: | Calcium channels |
Control Compound: | Isradipine |
Study Type: | Organ bath |
Functional Endpoint: | Relaxation |
Contractile Force in Electrically Stimulated Human Colon (Acetylcholine Esterase)
Reference number: B086
Assay type: | GI Tract |
Tissue: | Human Stomach (Healthy) |
Target: | Acetylcholine esterase |
Control Compound: | Galantamine |
Study Type: | EFS organ bath |
Functional Endpoint: | Contractility |
Contractile Force in Electrically Stimulated Human Stomach (Motilin Receptor)
Reference number: B092
Assay type: | GI Tract |
Tissue: | Human Stomach (Healthy) |
Target: | Motilin receptor |
Control Compound: | Erythromycin |
Study Type: | EFS organ bath |
Functional Endpoint: | Contractility |
Permeability in Healthy Human Gastrointestinal Mucosa
Reference number: B093
Assay type: | GI Tract |
Tissue: | Human Gastrointestinal Mucosa |
Target: | N/A |
Control Compound: | Multiple |
Study Type: | Ussing chamber |
Functional Endpoint: | Permeability |
Ion Channel Function in Isolated Healthy Human Gastrointestinal Mucosa (Chloride Channels)
Reference number: B094
Assay type: | GI Tract |
Tissue: | Human Gastrointestinal Mucosa (Healthy) |
Target: | Chloride channels |
Control Compound: | Cholera toxin |
Study Type: | Ussing chamber |
Functional Endpoint: | Ion channel function |
Contractile Force in Electrically Stimulated Human Ventricular Trabeculae Muscle (Adrenoceptor)
Reference number: B095
Assay type: | Cardiac Muscle |
Tissue: | Human Ventricular Trabeculae Muscle (Healthy) |
Target: | Adrenoceptor |
Control Compound: | Isoprenaline |
Study Type: | EFS organ bath |
Functional Endpoint: | Contractility |
Contractile Force in Eletrically Stimulated Human Ventricular Trabeculae Muscle (Acetylcholine Receptor)
Reference number: B096
Assay type: | Cardiac Muscle |
Tissue: | Human Ventricular Trabeculae Muscle (Healthy) |
Target: | Acetylcholine receptor |
Control Compound: | Acetylcholine |
Study Type: | EFS organ bath |
Functional Endpoint: | Contractility |
Vasoconstriction in Human Subcutaneous Resistance Arteries (5-HT Receptor)
Reference number: B097
Assay type: | Blood Vessels |
Tissue: | Human Subcutaneous Resistance Artery (Healthy) |
Target: | 5-HT receptor |
Control Compound: | 5-HT |
Study Type: | Wire Myography |
Functional Endpoint: | Vasoconstriction |
Bronchodilatation in Healthy Human Secondary Airways (VIP & PACAP Receptors)
Reference number: B098
Assay type: | Respiratory |
Tissue: | Human Secondary Airways (Healthy) |
Target: | VIP & PACAP |
Control Compound: | Vasoactive Intestinal Polypeptide (VIP) |
Study Type: | Organ bath |
Functional Endpoint: | Bronchodilatation |
Bronchoconstriction in Healthy Human Tertiary or Lower Airways (Lopoxin, Oxoeiconsanoid and Resolvin E1)
Reference number: B099
Assay type: | Respiratory |
Tissue: | Human Secondary Airways (Healthy) |
Target: | VIP & PACAP |
Control Compound: | Vasoactive Intestinal Polypeptide (VIP) |
Study Type: | Organ bath |
Functional Endpoint: | Bronchodilatation |
IBD Culture Study Crohn’s or Ulcerative Colitis (UC)
Reference number: B106
Tissue: | Inflammatory Bowel Disease (IBD) |
Target: | p38 MAP Kinase |
Control Compound: | BIRB796 |
Study Type: | Ex vivo Cultures |
Functional Endpoint: | Inflammation |
Contraction in Human Bladder (Muscarinic – Carbachol)
Reference number: B107
Assay type: | GU |
Tissue: | Human Bladder (Healthy) |
Target: | Muscarinic receptors |
Control Compound: | Carbachol |
Study Type: | Organ bath |
Functional Endpoint: | Contractility |
Contraction, Relaxation in Human Bladder Electrically Stimulated
Reference number: B108
Assay type: | GU |
Tissue: | Human Bladder (Healthy) |
Target: | Muscarinic/ beta-adrenergic receptors/ ion channels |
Control Compound: | Carbachol/ isoproterenol/ retigabine |
Study Type: | Organ bath |
Functional Endpoint: | Modulation of EFS-induced contractions |
Permeability in IBD Human Gastrointestinal Mucosa
Reference number: B109
Assay type: | Inflammatory Bowel Disease (IBD) |
Tissue: | Human Diseased (IBD) Gastrointestinal Mucosa |
Target: | N/A |
Control Compound: | Multiple |
Study Type: | Ussing chamber |
Functional Endpoint: | Permeability |
Pulmonary Artery Tone
Reference number: B110
Assay type: | GU / Blood Vessels |
Tissue: | Human Pulmonary Artery (Healthy) / Human Pulmonary Artery (Healthy – Denuded) |
Target: | Muscarinic Receptors/ Angiotensin receptor/ Nitric oxide donor/ Endothelin receptor/ Prostacyclin receptor/ Prostaglandin EP2 receptor/ Prostaglandin EP4 receptor/ Beta adrenergic receptor |
Control Compound: | Acetylcholine/ Angiotensin II/ Sildenafil/ U46619/ Endothelin-1/ Iloprost/ Bosentan/ Wire Myography |
Study Type: | Organ bath |
Functional Endpoint: | Contractile force/ Contraction/ Relaxation/ Vasoconstriction/ Vasodilatation |
Skin Inflammation LPS (Acne) (Systemic/Topical)
Reference number: B111
Assay type: | Skin |
Tissue: | Human Skin Biopsies (Healthy) |
Target: | TLR4/TLR2 Pathway/ Glucocorticoid receptors/ NLRP3 Inflammasome |
Control Compound: | Betnovate/ Nitric Oxide |
Study Type: | Ex vivo cultures |
Functional Endpoint: | Cytokine release |
Lung PCLS Culture
Reference number: B112
Assay type: | Respiratory |
Tissue: | Human Precision Cut Lung Slice (PCLS) |
Target: | TLR4/TLR2 Pathway/ Glucocorticoid receptors/ NLRP3 Inflammasome |
Control Compound: | Fluticasone/ Roflumilast |
Study Type: | Ex vivo cultures |
Functional Endpoint: | Cytokine release |
Skin Culture Induced Psoriasis Model (Systemic/Topical)
Reference number: B113
Assay type: | Skin |
Tissue: | Human Skin Biopsies (Healthy) |
Target: |
Glucocorticoid receptors/ Retinoid receptors/ Th17 Pathway |
Control Compound: | Retigabine/ Betnovate/ Calcipotriol/ ROR gamma antagonist GSK2981278/ Dovonex (topical calcipotriol)/ Dovobet (topical calcipotriol plus Betamethasone)/ Zorac/ Dermovate/ Phase1/Phase 2 metabolic enzymes |
Study Type: | Ex vivo cultures |
Functional Endpoint: | Cytokine release/ Gene Expression |
Relaxation in Human LES
Reference number: B114
Assay type: | Gastrointestinal (GI) Tract |
Tissue: | Human Lower esophageal sphincter |
Target: | TGR5 receptor |
Control Compound: | Carbachol/ Isoprenaline |
Study Type: | Organ bath |
Functional Endpoint: | Contractile force/ Relaxation |
Contraction in Human LES
Reference number: B115
Assay type: | Gastrointestinal (GI) Tract |
Tissue: | Human Lower esophageal sphincter |
Target: | TGR5 receptor |
Control Compound: | Carbachol/ Isoprenaline |
Study Type: | Organ bath |
Functional Endpoint: | Contractile force/Contraction |
GI Metabolism
Reference number: B116
Assay type: | Gastrointestinal (GI) Tract |
Tissue: | Human Colon/ Human Gastrointestinal Mucosa (Healthy) |
Target: | Phase1/Phase 2 metabolic enzymes |
Control Compound: | Phase1/Phase 2 metabolic enzymes |
Study Type: | Ussing chamber |
Functional Endpoint: | Metabolism |
Healthy Skin Culture
Reference number: B117
Assay type: | Skin |
Tissue: | Human Skin Biopsies (Healthy) |
Target: | Study Dependant |
Control Compound: | LPS |
Study Type: | Ex vivo cultures |
Functional Endpoint: | Inflammation |
Skin Biopsies Atopic Dermatitis (Systemic/Topical)
Reference number: B118
Assay type: | Skin |
Tissue: | Skin Disease Biopsies |
Target: | Study Dependant |
Control Compound: | Betamethasone |
Study Type: | Ex vivo cultures |
Functional Endpoint: | Inflammation |
Skin Biopsies Atopic Psoraisis (Systemic/Topical)
Reference number: B119
Assay type: | Skin |
Tissue: | Skin Disease Biopsies |
Target: | Study Dependant |
Control Compound: | Betamethasone |
Study Type: | Ex vivo cultures |
Functional Endpoint: | Inflammation |
Skin Inflammation PHA (Systemic/Topical)
Reference number: B120
Assay type: | Skin |
Tissue: | Human Skin Biopsies (Healthy) |
Target: | Study Dependant |
Control Compound: | Betamethasone |
Study Type: | Ex vivo cultures |
Functional Endpoint: | Inflammation |
Skin Culture Induced Atopic Dermatitis Model (Systemic/Topical)
Reference number: B121
Assay type: | Skin |
Tissue: | Human Skin Biopsies (Healthy) |
Target: | TH2 Pathway |
Control Compound: | Betamethasone |
Study Type: | Ex vivo cultures |
Functional Endpoint: | Inflammation |
Mouse IBD Model – Crohn’s or Ulcerative Colitis (UC)
Reference number: B122
Assay Type: | Inflammatory Bowel Disease (IBD) |
Tissue: | Murine GI mucosal explants (IBD) |
Study Type: | Ex vivo cultures |
Functional Endpoint: | Inflammation |
Contractility of Rat Uterus (Vasopressin & Oxytocin Receptor)
Reference number: B123
Assay type: | Genitourinary (GU) |
Tissue: | Rat uterus (healthy) |
Target: | Vasopressin & oxytocin receptors |
Control Compound: | Oxytocin |
Study Type: | Organ bath |
Functional Endpoint: | Contractility |
Ex Vivo Skin Explants and Bioengineered 3D Human Skin In Vitro Models
Reference number: B124
Assay type: | Skin |
Tissue: | Human Skin Disease Biopsies, Human Skin (Surgical) |
Target: | Study dependant |
Control Compound: | Study dependant |
Study Type: | 3D Cell Culture |
Functional Endpoint: | Study dependant |
3D Bioengineered Model for Inflammatory Bowel Disease
Reference number: B125
Assay type: | Inflammatory Bowel Disease (IBD) |
Tissue: | Bioengineered human IBD tissue |
Target: | Study dependant |
Control Compound: | BIRB796, Mesalamine/5-ASA, Prednisolone, Tofacitinib |
Study Type: | 3D Cell Culture |
Functional Endpoint: | Inflammation, Fibrosis/Remodelling, Cytokine release, Gene expression |
Transport Studies in 3D Bioengineered IBD Model
Reference number: B126
Assay type: | Inflammatory Bowel Disease (IBD) |
Tissue: | Bioengineered human IBD tissue |
Target: | N/A |
Control Compound: | BIRB796, Mesalamine/5-ASA, Prednisolone, Tofacitinib |
Study Type: | 3D Cell Culture |
Functional Endpoint: | Ion channel function, Permeability, Metabolism |